Process

As I write this blog, it is quite likely that a transformation is taking place somewhere. This change could be small or, at other times, so big that it can lead to a huge impact all around. And the past few years have been a testimony to evolution across a wide array of industries. I…

I vividly remember the day when I was introduced to the world of a cleanroom. I was pretty much cognizant of the functioning and essence of a cleanroom until I was handed over a comprehensive manual that discussed each component of a cleanroom in detail. HEPA filters, Laminar Air flows, Air Showers, the list went…

The role of granulation in tablet manufacturing is indisputable. The formation of granules, if characterized optimally, enhances the uniformity of the API, and has significant impact on the tablet’s flowability and compressibility. As we all know, several manufacturing unit operations are undertaken prior to tablet compressing, including wet granulation to agglomerate ‘fines’ and form appropriate…

Derived from the word ‘Beta’ and ‘Carrot’, ‘Beta Carotene’, is a plant pigment found in carrots. Beta Carotene while entering our body gets converted into Vitamin A which is an essential micronutrient. It helps one maintain good vision, lining of respiratory tract, regulation of skin cells and proteins. All carotenoids, including beta-carotene, also possess antioxidant…

The following discussion is primarily in the context of development of expired Generic or Patent pharmaceutical dosage forms, which can be pharmaceutically and bio pharmaceutically equivalent to an established international brand leader (Innovator). However, it is neither intended nor should it be perceived as a New Molecule (New Drug Product) Development. While considering a new…

Back during the World War II, several military jargons came to be used in discussions on strategic planning and execution. In tune with the ongoing wars all around, the top decision making authorities then began to be referred to as “Think Tank”. However, over a period of time, the terminology found its reference broadened as…

Granulation that forms the core component of the pharmaceutical industry continues to grow with improved technologies and accelerated advancement.  Apparently, High Shear Granulation (HSG) technique that offers an enhanced shaping process has been widely accepted as the optimum choice of tablet granulation method. Considering its slow moving heavy duty beater assembly coupled with a fast…

Even as the severity of the pandemic continues to hound us now and then, a few thumb rules always need to be adhered to until the pandemic is completely wiped out. Amidst the masks, sanitizers and frequent hand washing, there is also an equally known yet less discussed atmosphere surrounding us. If the supposedly zero…

What are the ideal properties of a good tablet granulation? Again a very loaded question but a very frequently asked question too. Let us try to identify the ideal properties and try to give them some usable numbers and figures. The properties of a good granulation can be defined as below: Flowability Optimum Moisture content Good…